Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 20859-23-8, is researched, Molecular C4H5BrO4, about An efficient synthesis of enantiomerically pure (R)-(2-benzyloxyethyl)oxirane from (S)-aspartic acid, the main research direction is benzyloxyethyloxirane; oxirane benzyloxyethyl.Synthetic Route of C4H5BrO4.
A 3-step synthesis of the title compound (I) from (S)-aspartic acid (II) is described. Thus, II reacted with NaNO2/KBr to give (S)-(-)bromosuccinic acid which was reduced to (S)-2-bromo-1,4-butanediol (III). III was treated with NaH/THF and PhCH2Br/tetrabutylammonium iodide to give I in 78% yield. The overall yield of this process is 65% and the enantiomeric purity (ep) of the product is greater than 99%.
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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”