With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7787-70-4,Copper(I) bromide,as a common compound, the synthetic route is as follows.,7787-70-4
Example 1 2-(Carboxy-5-nitro-phenyl)malonic acid dimethyl ester A solution of 2-chloro-4-nitrobenzoic acid (75 g, 372 mmol) in dimethyl malonate (900 mL, 20 equivalents) was degassed with nitrogen for 15 min. Copper (I) bromide (5.4 g, 37 mmol) was added in one portion. Sodium methoxide (48.3 g, 894 mmol) was added in one portion to the solution while stirring and the contents exothermed to 48 C. Fifteen minutes later, the contents were heated to 70 C. for 24 hrs. The reaction was complete by nmr. Water (900 mL) was added to the cooled reaction followed by hexanes (900 mL). The aqueous layer was separated, toluene (900 mL) added, the solution filtered through Celite, and the aqueous layer separated. Fresh toluene (1800 mL) was added to the aqueous layer and the biphasic mixture acidified with 6 N aqueous HCl (90 mL). A white precipitate formed and the contents were stirred for 18 hrs. The product was filtered off and dried to give a white solid, 78.1 g (70%, mp 153 C.). IR 2923, 2853, 1750, 1728, 1705, 1458, 1376, 1352, 1305, 1261 cm-1.1 H NMR (CD3)2 SO delta8.37(d,J=2 Hz, 1H), 8.30 (d,J=1 Hz,2H), 5.82(s, 1H),3.83 (s,6H).13 C NMR (CD3)2 SOdelta168.0, 167.3, 149.4, 137.1, 135.8, 132.5, 125.4, 123.7, 54.5, 53.4.Anal. Calcd for C11 H10 NO8:C,48.49; H,3.73; N, 4.71. Found:C, 48.27; H,3.72; N, 4.76.
As the paragraph descriping shows that 7787-70-4 is playing an increasingly important role.
Reference£º
Patent; Pfizer Inc; US5968950; (1999); A;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”