Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: [Ir(dtbbpy)(ppy)2]PF6, is researched, Molecular C40H40F6IrN4P, CAS is 676525-77-2, about Enantioselective α-Trifluoromethylation of Aldehydes via Photoredox Organocatalysis.Formula: C40H40F6IrN4P.
The first enantioselective, organocatalytic α-trifluoromethylation and α-perfluoroalkylation of aldehydes was accomplished using a readily available iridium photocatalyst and a chiral imidazolidinone catalyst. A range of α-trifluoromethyl and α-perfluoroalkyl aldehydes were obtained from com. available perfluoroalkyl halides with high efficiency and enantioselectivity, though typically they were reduced in situ with NaBH4 to the corresponding alcs. However, the α-trifluoromethyl aldehydes were shown to be versatile precursors for the construction of a variety of enantioenriched trifluoromethylated building blocks.
Different reactions of this compound([Ir(dtbbpy)(ppy)2]PF6)Formula: C40H40F6IrN4P require different conditions, so the reaction conditions are very important.
Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”