So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Walczak, Katarzyna; Kazimierczak, Paulina; Szalast, Karolina; Plech, Tomasz researched the compound: 4-Hydroxyquinoline-2-carboxylic Acid( cas:492-27-3 ).Synthetic Route of C10H7NO3.They published the article 《UVB Radiation and Selected Tryptophan-Derived AhR Ligands-Potential Biological Interactions in Melanoma Cells》 about this compound( cas:492-27-3 ) in International Journal of Molecular Sciences. Keywords: melanoma tryptophan AhR ligands UVB radiation; UVB; aryl hydrocarbon receptor; kynurenic acid; kynurenine; melanoma; necrosis; proliferation; tryptophan; tumor cell transendothelial cell migration assay. We’ll tell you more about this compound (cas:492-27-3).
Excessive UV exposure is considered the major environmental factor in melanoma progression. Human skin is constantly exposed to selected tryptophan-derived aryl hydrocarbon receptor (AhR) ligands, including kynurenine (KYN) and kynurenic acid (KYNA), as they are endogenously produced and present in various tissues and body fluids. Importantly, recent studies confirmed the biol. activity of KYN and KYNA toward melanoma cells in vitro. Thus, in this study, the potential biol. interactions between UVB and tryptophan metabolites KYN and KYNA were studied in melanoma A375, SK-MEL-3, and RPMI-7951 cells. It was shown that UVB enhanced the antiproliferative activity of KYN and KYNA in melanoma cells. Importantly, selected tryptophan-derived AhR ligands did not affect the invasiveness of A375 and RPMI-7951 cells; however, the stimulatory effect was observed in SK-MEL-3 cells exposed to UVB. Thus, the effect of tryptophan metabolites on metabolic activity, cell cycle regulation, and cell death in SK-MEL-3 cells exposed to UVB was assessed. In conclusion, taking into account that both UVB radiation and tryptophan-derived AhR ligands may have a crucial effect on skin cancer formation and progression, these results may have a significant impact, revealing the potential biol. interactions in melanoma cells in vitro.
Different reactions of this compound(4-Hydroxyquinoline-2-carboxylic Acid)Synthetic Route of C10H7NO3 require different conditions, so the reaction conditions are very important.
Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”