7758-99-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Copper(II) sulfate pentahydrate, cas is 7758-99-8,the copper-catalyst compound, it is a common compound, a new synthetic route is introduced below.
18 g of copper sulphate and 6.75 g of sodium bromide were added to 150 ML of D. M water in a 3 necked round bottom flask. The contents of flask were heated to 76-78 C to obtain a clear solution. 6g of sodium metabisulphite was then added to it in portions and stirred for 15 min. The reaction mixture was cooled to 30 2 C. CuBr solid was filtered. To 150 g of compound of formula 2 was added 1.5 1 of acetone and 600 ml of methanol. The contents of the flask were cooled to 18-20 C. 245 ml of aqueous HBR was added to the above reaction mixture at 18-20 C in a single charge. Cool the contents of the flask to 0-2 C. 120ML of 50% w/v aqueous sodium nitrite solution was added slowly to the reaction mixture by maintaining the temperature between 0-2 C, over a period of 30 minutes. The reaction mixture was maintained for 15 minutes at 0-2 C. The temperature was raised to 20-22 C. A solution of 246g of acrylamide in 900ML of acetone was added at 22-23 C in single charge. The reaction mixture was stirred for 10 minutes at 23-24 C, 4. 6g of cuprous bromide was added in a single charge under vigorous stirring and the reaction mixture maintained for 2 hours at 30-35 C. After completion of the reaction, acetone and methanol were. distilled off completely to obtain thick liquid mass. A solution of 150 g of sodium bicarbonate in 3.0 1 of D. M water was prepared. 600ML of hexane was added to it and stirred to get a clear biphasic solution. The reaction mixture was gradually quenched into above flask containing aqueous sodium bicarbonate and hexane solution over a period of 30 minutes at 23-35 C followed by stirring for 2 hours. The product was filtered and the product cake washed with D. M. Water followed by hexane and dried. The crude product obtained was suspended in water and stirred for 1 hour at 25-30 C. The product was filtered and cake washed with D. M. Water followed by hexane. The product thus obtained was suspended in hexane and stirred for 2 hours at 35- 40C. It was filtered and washed with hexane and dried to get compound of formula 3.
The chemical industry reduces the impact on the environment during synthesis,7758-99-8,Copper(II) sulfate pentahydrate,I believe this compound will play a more active role in future production and life.
Reference£º
Patent; SUN PHARMACEUTICAL INDUSTRIES LIMITED; WO2004/108721; (2004); A1;,
Copper catalysis in organic synthesis – NCBI
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”