So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Cathomas, Flurin; Guetter, Karoline; Seifritz, Erich; Klaus, Federica; Kaiser, Stefan researched the compound: 4-Hydroxyquinoline-2-carboxylic Acid( cas:492-27-3 ).Computed Properties of C10H7NO3.They published the article 《Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder》 about this compound( cas:492-27-3 ) in Scientific Reports. Keywords: schizophrenia major depressive disorder cognitive deficit quinolinic acid. We’ll tell you more about this compound (cas:492-27-3).
Tryptophan and its catabolites (TRYCATs) have been suggested to link peripheral immune system activation and central neurotransmitter abnormalities with relevance to the etio-pathophysiol. of schizophrenia (SZ) and major depressive disorder (MDD). The relationship to different psychopathol. dimensions within these disorders however remains to be elucidated. We thus investigated potential group differences of tryptophan, kynurenine, kynurenic acid, 3-hydroxy kynurenine and quinolinic acid in the plasma of 19 healthy controls (HC), 45 patients with SZ and 43 patients with MDD and correlated plasma proteins with the “”motivation and pleasure”” dimension and cognition. After correcting for the covariates age, sex, body mass index, smoking and medication, patients with MDD showed lower kynurenine and 3-hydroxy kynurenine levels compared to HC. Quinolinic acid correlated neg. with composite cognitive score in patients with SZ, indicating that more severe cognitive impairments were associated with increased plasma levels of quinolinic acid. No correlations were found in patients with MDD. These results indicate that MDD and SZ are associated with dysregulation of the kynurenine pathway. Quinolinic acid might be specifically implicated in the pathophysiol. of cognitive deficits in patients with SZ. Further studies are needed to determine whether TRYCATs are causally involved in the etiol. of these neuropsychiatric disorders.
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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”