Tag: 361.6842

De Novo Synthesis of Bacteriochlorins Bearing Four Trideuteriomethyl Groups was written by Jing, Haoyu;Tang, Qun;Bocian, David F.;Lindsey, Jonathan S.. And the article was included in Organics in 2022.HPLC of Formula: 34946-82-2 This article mentions the following:

Site-specific introduction of isotopes in tetrapyrrole macrocycles provides the foundation for probing physicochem. features germane to photosynthetic energy-transduction processes, but has chiefly been done with porphyrins rather than the more biol. relevant hydroporphyrin analogs of native photosynthetic pigments. A prior study incorporated pairwise 13C or 15N atoms in the skeleton of a bacteriochlorin containing a gem-di-Me group in each pyrroline ring. Here, a complementary effort is reported that installs deuterium atoms in substituents at the perimeter of a bacteriochlorin. Thus, perdeuteriated 3-methyl-2,4-pentanedione was converted in an 8-step synthesis via the intermediacy of tert-Bu 5-formyl-3,4-bis(trideuteriomethyl)pyrrole-2-carboxylate to the 2,3,12,13-tetrakis(trideuteriomethyl)-8,8,18,18-tetramethylbacteriochlorin (BC-2). The fidelity of isotope substitution was maintained throughout the synthesis. Resonance Raman spectroscopy of the copper chelate (CuBC-2) revealed that addition of the four β-pyrrolic substituents alone is not sufficient to account for the vibronic complexity observed for the copper chelate of bacteriochlorophyll a (CuBChl a). The increased vibronic activity exhibited by the natural pigments and CuBChl a must arise from the increased structural complexity of the macrocycle. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2HPLC of Formula: 34946-82-2).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The transition metal-catalyzed chemical transformation of organic electrophiles and organometallic reagents has turned up as an exceedingly robust synthetic tool. Copper of different valence states can be used to catalyze the coupling reaction, especially the Ullmann coupling reaction. HPLC of Formula: 34946-82-2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Regioselective Alkylpolyfluoroarylation of Styrenes by Copper-Catalyzed C(sp³)-H and C(sp²)-H Double Activation was written by Zheng, Chenggong;Yan, Fangpei;Liu, Yaomei;Chen, Rui;Zheng, Kaiting;Xiao, Hua;Li, Xiao-Xuan;Feng, Yi-Si;Fan, Shilu. And the article was included in Organic Letters in 2022.Application of 34946-82-2 This article mentions the following:

A novel dehydrogenative dicarbofunctionalization of vinyl arenes ArCH=CHR (Ar = Ph, thiophen-2-yl, 2H-1,3-benzodioxol-5-yl, etc.; R = H, Me) with polyfluoroarenes I (R¹ = F, OMe, Ph, etc.) and inactivated alkanes such as cyclohexane, cyclopentane, cycloheptane, etc. enabled by copper catalysis has been accomplished under mild conditions. This transformation provides a regioselective route to highly functionalized polyfluoroaryl compds II (R² = cyclopentyl, cyclohexyl, cycloheptyl, etc.) that occur as structural scaffolds in a variety of pharmaceuticals and materials. Preliminary mechanistic studies indicate that the carbon-based radical and copper intermediate are involved in the reaction, and the reaction pathway is dominated by the bond dissociation energy (BDE) of C(sp³)-H bonds. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Application of 34946-82-2).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The transition metal-catalyzed chemical transformation of organic electrophiles and organometallic reagents has turned up as an exceedingly robust synthetic tool. It is clear from the impact copper catalysis has had on organic synthesis that copper should be considered a first line catalyst for many organic reactions.Application of 34946-82-2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Asymmetric Alkynylation of Tertiary Carbon-Centered Radical via Copper-Catalyzed Radical Relay was written by Wu, Dunqi;Wu, Lianqian;Chen, Pinhong;Liu, Guosheng. And the article was included in Chinese Journal of Chemistry in 2022.Application of 34946-82-2 This article mentions the following:

Alkynes are frequently found in a high proportion of natural products and bioactive moleculars, as well as a common synthon in organic synthesis, which can be easily transformed to an alkenyl, alkyl, heteroaryl, or carboxylic acid group. The enantioselective construction of alkyne substituted all carbon quaternary stereocenters is rarely reported and still a big challenge. As part of the continuous effort on developing asym. radical transformations, it was found that introducing an amidyl group (CONHAr) adjacent to the tertiary carbon radical could enable the asym. radical coupling with alkyne reagents. The amidyl group may stabilize the tertiary carbon radical or coordination with the chiral copper catalyst. Herein, a copper-catalyzed asym. trifluoromethyl-alkynylation of α-aryl substituted acrylamides, which provides a straightforward and efficient access to chiral quaternary all-carbon centers bearing alkynyl groups in good yields and enantioselectivities is reported. This reaction was also applied for the synthesis of chiral functionalized dipeptide. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Application of 34946-82-2).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. Transition metal-catalyzed chemical transformation of organic electrophiles and organometallic reagents belong to the most important cross-coupling reaction in organic synthesis. Copper nanoparticles can also catalyze the coupling reaction of phenols, thiols, xanthogenates, nitrogen-containing nucleophiles, selenium ruthenium nucleophiles and the like.Application of 34946-82-2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Understanding the effect of structural changes on slow magnetic relaxation in mononuclear octahedral copper(II) complexes was written by Marcinkowski, Dawid;Adamski, Ariel;Kubicki, Maciej;Consiglio, Giuseppe;Patroniak, Violetta;Slusarski, Tomasz;Acikgoz, Muhammed;Szeliga, Daria;Vadra, Nahir;Karbowiak, Miroslaw;Stefaniuk, Ireneusz;Rudowicz, Czeslaw;Gorczynski, Adam;Korabik, Maria. And the article was included in Dalton Transactions in 2022.Quality Control of Copper(II) trifluoromethanesulfonate This article mentions the following:

Current advances in mol. magnetism are aimed at the construction of mol. nanomagnets and spin qubits for their use as high-d. data storage materials and quantum computers. Mononuclear coordination compounds with low spin values of S = 1/2 are excellent candidates for this endeavour, but knowledge of their construction via rational design is limited. This particularly applies to the single copper(II) spin center, having been only recently demonstrated to exhibit slow relaxation of magnetization in the appropriate octahedral environment. The authors thus prepared a unique organic scaffold that would allow one to gain in-depth insight into how purposeful structural differences affect the slow magnetic relaxation in monometallic, transition metal complexes. As a proof-of-principle, one can construct two, structurally very similar complexes with isolated Cu(II) ions in an octahedral ligand environment, the magnetic properties of which differ significantly. The differences in structural symmetry effects and in magnetic relaxation are corroborated with exptl. techniques and theor. approaches, showing how symmetry distortions and crystal packing affect the relaxation behavior in these isolated Cu(II) systems. The unique organic platform can be efficiently used for the construction of various transition-metal ion systems in the future, effectively providing a model system for investigation of magnetic relaxation via targeted structural distortions. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Quality Control of Copper(II) trifluoromethanesulfonate).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The transition metal-catalyzed chemical transformation of organic electrophiles and organometallic reagents has turned up as an exceedingly robust synthetic tool. It is clear from the impact copper catalysis has had on organic synthesis that copper should be considered a first line catalyst for many organic reactions.Quality Control of Copper(II) trifluoromethanesulfonate

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Effective Preparation of [¹⁸F]Flumazenil Using Copper-Mediated Late-Stage Radiofluorination of a Stannyl Precursor was written by Haskali, Mohammad B.;Roselt, Peter D.;O’Brien, Terence J.;Hutton, Craig A.;Ali, Idrish;Vivash, Lucy;Jupp, Bianca. And the article was included in Molecules in 2022.Formula: C2CuF6O6S2 This article mentions the following:

[¹⁸F]Flumazenil 1 ([¹⁸F]FMZ) is an established positron emission tomog. (PET) radiotracer for the imaging of the gamma-aminobutyric acid (GABA) receptor subtype, GABAA in the brain. The production of [¹⁸F]FMZ 1 for its clin. use has proven to be challenging, requiring harsh radiochem. conditions, while affording low radiochem. yields. Fully characterized, new methods for the improved production of [¹⁸F]FMZ 1 are needed. We investigate the use of late-stage copper-mediated radiofluorination of aryl stannanes to improve the production of [¹⁸F]FMZ 1 that is suitable for clin. use. Mass spectrometry was used to identify the chem. byproducts that were produced under the reaction conditions. The radiosynthesis of [¹⁸F]FMZ 1 was fully automated using the iPhase FlexLab radiochem. module, affording a 22.2 ± 2.7% (n = 5) decay-corrected yield after 80 min. [18F]FMZ 1 was obtained with a high radiochem. purity (>98%) and molar activity (247.9 ± 25.9 GBq/μmol). The copper-mediated radiofluorination of the stannyl precursor is an effective strategy for the production of clin. suitable [18F]FMZ 1. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Formula: C2CuF6O6S2).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The applications of Copper-based nanoparticles have received great attention due to low toxicity and inexpensive, earth-abundant. Copper of different valence states can be used to catalyze the coupling reaction, especially the Ullmann coupling reaction. Formula: C2CuF6O6S2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Ligand-Enabled Copper-Catalyzed Regio- and Stereoselective Allylboration of 1-Trifluoromethylalkenes was written by Kojima, Yuki;Nishii, Yuji;Hirano, Koji. And the article was included in Organic Letters in 2022.Formula: C2CuF6O6S2 This article mentions the following:

A Cu-catalyzed regio- and stereoselective allylboration of 1-trifluoromethylalkenes with bis(pinacolato)diboron (pinB-Bpin) and allylic chlorides was developed to form functionalized trifluoromethylated products with high diastereoselectivity. The key to success is the judicious choice of Cs₂CO₃ base and t-Bu-modified dppe-type ligand, which enables the otherwise challenging high catalyst turnover and suppression of the competing defluorination side reaction from an alkylcopper intermediate. The product derivatization of the resulting Bpin moiety can deliver diverse CF₃-containing mols. with high stereochem. fidelity. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Formula: C2CuF6O6S2).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The applications of Copper-based nanoparticles have received great attention due to the earth-abundant, inexpensive and low toxicity. The copper-mediated C-C, C-O, C-N, and C-S bond formation is a part of one oldest reaction, emphasizing the Ullmann cross-coupling reaction.Formula: C2CuF6O6S2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Hybrid Quinoline Telluroether Ligand Derived Copper and Silver Complexes: Synthesis, Structural and Electronic Properties was written by Raju, Saravanan;Singh, Harkesh B.;Kumar, Sangit. And the article was included in European Journal of Inorganic Chemistry in 2022.Reference of 34946-82-2 This article mentions the following:

The tetradentate organotelluroether (C₉H₆NTe)₂CH₂ ligand was synthesized and its coordination behavior with a stoichiometric amount of Cu(II) and Ag(I) perchlorate and triflate salts was exptl. studied. The isolated ligand and metal complexes were characterized by multinuclear (¹H, ¹³C, ¹²⁵Te) NMR spectroscopy, single crystal x-ray diffraction, and DFT calculations The x-ray anal. revealed the formation of self-assembled bimetallic complexes with the mol. formula of 2[M(C₉H₆NTe)₂CH₂]⁺ X^– [M⁺ = Cu, Ag; X^– = ClO₄, CF₃SO₃]. Further, it was noticed that the metal ions act as a bridging unit to form cationic 8-membered metallamacrocycles in the chair conformation. The atoms in mol. (AIM) and noncovalent interactions (NCI) anal. display a weak intramol. Te···Te interaction. Natural bond orbital (NBO) calculations suggest that the Te has a rich electron donating ability toward metal ions than the quinoline N in the complexes. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Reference of 34946-82-2).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. Copper catalyst has received great attention owing to the low toxicity and low cost. It is clear from the impact copper catalysis has had on organic synthesis that copper should be considered a first line catalyst for many organic reactions.Reference of 34946-82-2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Tf₂O- and Cu(OTf)₂-Assisted Acylamination Reaction of Unactivated Alcohols with Nitriles: A One-Pot P(IV) Activation, Stereoretention in Cycloalkanols and Deprotection Approach was written by Bhat, Mohammad Yaqoob;Ahmed, Sajjad;Ahmed, Qazi Naveed. And the article was included in Journal of Organic Chemistry in 2022.Category: copper-catalyst This article mentions the following:

Described herein is a simple, novel, one-pot acylamination reaction of unactivated alcs. This reaction employs the combination of PCl₃ and triflic anhydride (Tf₂O) or copper triflate Cu(OTf)₂, which serves as a source of P(IV)-activated complex for nitriles to react under the Ritter-type mechanism. The synthetic utility of Tf₂O-promoted reactions was demonstrated by its effectiveness to generate different acylaminated products. By employing Cu(OTf)₂, this method represented a rare example of α-selective acylamination reaction. With chiral cycloalkanols, using the Cu(OTf)₂-promoted procedure, acylaminated products were formed with complete retention of configuration. The synthetic utility of the copper-assisted reaction in acetonitrile was readily demonstrated as a mild deprotection strategy. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Category: copper-catalyst).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The applications of Copper-based nanoparticles have received great attention due to the earth-abundant, inexpensive and low toxicity. It is clear from the impact copper catalysis has had on organic synthesis that copper should be considered a first line catalyst for many organic reactions.Category: copper-catalyst

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

π-Extended Ligands in Two-Coordinate Coinage Metal Complexes was written by Muniz, Collin N.;Schaab, Jonas;Razgoniaev, Anton;Djurovich, Peter I.;Thompson, Mark E.. And the article was included in Journal of the American Chemical Society in 2022.Quality Control of Copper(II) trifluoromethanesulfonate This article mentions the following:

Two-coordinate carbene-M^I-amide (cMa, M^I = Cu, Ag, Au) complexes have emerged as highly efficient luminescent materials for use in a variety of photonic applications due to their extremely fast radiative rates through thermally activated delayed fluorescence (TADF) from an interligand charge transfer (ICT) process. A series of cMa derivatives was prepared to examine the variables that affect the radiative rate, with the goal of understanding the parameters that control the radiative TADF process in these materials. Authors find that blue-emissive complexes with high photoluminescence efficiencies (Φ_PL > 0.95) and fast radiative rates (k_r = 4 x 10⁶ s^-1) can be achieved by selectively extending the π-system of the carbene and amide ligands. Of note is the role played by the increased separation between the hole and electron in the ICT excited state. Anal. of temperature-dependent luminescence data and theor. calculations indicate that the hole-electron separation exerts a primary effect on the energy gap between the lowest-energy singlet and triplet states (ΔE_ST) while keeping the radiative rate for the singlet state relatively unchanged. This interpretation provides guidelines for the design of new cMa derivatives with even faster radiative rates in addition to those with slower radiative rates and thus extended excited state lifetimes. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Quality Control of Copper(II) trifluoromethanesulfonate).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The applications of Copper-based nanoparticles have received great attention due to low toxicity and inexpensive, earth-abundant. Copper nanoparticles can also catalyze the coupling reaction of nitrogen-containing nucleophiles, phenols, thiols, xanthogenates, selenium ruthenium nucleophiles and the like.Quality Control of Copper(II) trifluoromethanesulfonate

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”

Copper-catalysed synthesis of trifluoromethyl allenes via fluoro-carboalkynylation of alkenes was written by Wang, Mengning;Wang, Qiuzhu;Ma, Mengtao;Zhao, Binlin. And the article was included in Organic Chemistry Frontiers in 2022.Related Products of 34946-82-2 This article mentions the following:

A copper-catalyzed synthesis of trifluoromethyl allenes utilizing readily available feedstocks under mild and environmentally friendly conditions was developed, which provided an operationally simple and practical platform for the preparation of substituted allenes with a broad substrate scope. Mechanistic explorations showed that a radical-mediated fluorocarboalkynylation and base-promoted step-wise isomerization of β-CF₃ alkynes were responsible for the formation of the desired allenes. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Related Products of 34946-82-2).

Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. Transition metal-catalyzed chemical transformation of organic electrophiles and organometallic reagents belong to the most important cross-coupling reaction in organic synthesis. The copper-mediated C-C, C-O, C-N, and C-S bond formation is a part of one oldest reaction, emphasizing the Ullmann cross-coupling reaction.Related Products of 34946-82-2

Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”