Quality Control of 4-Hydroxyquinoline-2-carboxylic Acid. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4-Hydroxyquinoline-2-carboxylic Acid, is researched, Molecular C10H7NO3, CAS is 492-27-3, about Natural molecules and neuroprotection: kynurenic acid, pantethine and α-lipoic acid. Author is Toth, Fanni; Cseh, Edina Katalin; Vecsei, Laszlo.
A review. The incidence of neurodegenerative diseases has increased greatly worldwide due to the rise in life expectancy. In spite of notable development in the understanding of these disorders, there has been limited success in the development of neuroprotective agents that can slow the progression of the disease and prevent neuronal death. Some natural products and mols. are very promising neuroprotective agents because of their structural diversity and wide variety of biol. activities. In addition to their neuroprotective effect, they are known for their antioxidant, anti-inflammatory and antiapoptotic effects and often serve as a starting point for drug discovery. In this review, the following natural mols. are discussed: firstly, kynurenic acid, the main neuroprotective agent formed via the kynurenine pathway of tryptophan metabolism, as it is known mainly for its role in glutamate excitotoxicity, secondly, the dietary supplement pantethine, that is many sided, well tolerated and safe, and the third mol., α-lipoic acid is a universal antioxidant. As a conclusion, because of their beneficial properties, these mols. are potential candidates for neuroprotective therapies suitable in managing neurodegenerative diseases.
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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”