Matencio, Adrian; Caldera, Fabrizio; Rubin Pedrazzo, Alberto; Khazaei Monfared, Yousef; K. Dhakar, Nilesh; Trotta, Francesco published the article 《A physicochemical, thermodynamical, structural and computational evaluation of kynurenic acid/cyclodextrin complexes》. Keywords: Kynurenic acid Cyclodextrin Inclusion complex Physicochem Stability; Cyclodextrin; Inclusion complex; Kynurenic acid; Physicochemical; Stability.They researched the compound: 4-Hydroxyquinoline-2-carboxylic Acid( cas:492-27-3 ).SDS of cas: 492-27-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:492-27-3) here.
In this work, the interaction between Kynurenic acid (KYNA) and several natural and modified cyclodextrins (CDs) is carried out. Among all the CD tested, HPβ-CD showed the strongest complexation constant (KF), with a value of 270.94 ± 29.80 M-1. Between natural (α- and β-) CDs, the complex of KYNA with β-CD was the most efficient. The inclusion complex of KYNA with CDs showed a strong influence of pH and temperature The KF value decreased at high pH values, when the pKa was passed. Moreover, an increase of the temperature caused a decrease in the KF values. The thermodn. parameters of the complexation (ΔH°, ΔS° and ΔG°) were studied with neg. entropy, enthalpy and spontaneity of the process at 25°C. Moreover, the inclusion complex was also characterized using FTIR and TGA. Finally, mol. docking calculations provided different interactions and their influence in the complexation constant
From this literature《A physicochemical, thermodynamical, structural and computational evaluation of kynurenic acid/cyclodextrin complexes》,we know some information about this compound(492-27-3)SDS of cas: 492-27-3, but this is not all information, there are many literatures related to this compound(492-27-3).
Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”