The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis and Screening of Stereochemically Diverse Combinatorial Libraries of Peptide Tertiary Amides》. Authors are Gao, Yu; Kodadek, Thomas.The article about the compound:(S)-2-Bromosuccinic acidcas:20859-23-8,SMILESS:O=C(O)[C@@H](Br)CC(O)=O).Product Details of 20859-23-8. Through the article, more information about this compound (cas:20859-23-8) is conveyed.
Large combinatorial libraries of N-substituted peptides would be an attractive source of protein ligands, because these compounds are known to be conformationally constrained, whereas standard peptides or peptoids are conformationally mobile. Here, the authors report an efficient submonomer solid-phase synthetic route to these compounds and demonstrate that it can be used to create high quality libraries. A model screening experiment and anal. of the hits indicates that the rigidity afforded by the stereocenters is critical for high affinity binding.
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Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”