In an article, author is Wu, Lianqian, once mentioned the application of 14347-78-5, Name is (R)-(2,2-Dimethyl-1,3-dioxolan-4-yl)methanol, molecular formula is C6H12O3, molecular weight is 132.1577, MDL number is MFCD00003213, category is copper-catalyst. Now introduce a scientific discovery about this category, Application In Synthesis of (R)-(2,2-Dimethyl-1,3-dioxolan-4-yl)methanol.
Anionic Bisoxazoline Ligands Enable Copper-Catalyzed Asymmetric Radical Azidation of Acrylamides
Asymmetric radical azidation for the synthesis of chiral alkylazides remains a tremendous challenge in organic synthesis. We report here an unprecedented highly enantioselective radical azidation of acrylamides catalyzed by 1 mol % of a copper catalyst. The substrates were converted to the corresponding alkylazides in high yield with good-to-excellent enantioselectivity. Notably, employing an anionic cyano-bisoxazoline (CN-Box) ligand is crucial to generate a monomeric Cu-II azide species, rather than a dimeric Cu-II azide intermediate, for this highly enantioselective radical azidation.
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Reference:
Copper catalysis in organic synthesis – NCBI,
,Special Issue “Fundamentals and Applications of Copper-Based Catalysts”