In 2019,Macromolecular Rapid Communications included an article by Wang, Jian; Wu, Zhigang; Wang, Guowei; Matyjaszewski, Krzysztof. Safety of Cupric bromide. The article was titled 《In Situ Crosslinking of Nanoparticles in Polymerization-Induced Self-Assembly via ARGET ATRP of Glycidyl Methacrylate》. The information in the text is summarized as follows:
Polymerization-induced self-assembly (PISA) and in situ crosslinking of the formed nanoparticles are successfully realized by activators regenerated by electron-transfer atom transfer radical polymerization (ARGET ATRP) of glycidyl methacrylate (GMA) or a mixture of GMA/benzyl methacrylate (BnMA) monomers in ethanol. Poly(oligo(ethylene oxide) Me ether methacrylate) was employed as macroinitiator/stabilizer, and a cupric bromide/tris(pyridin-2-ylmethyl)amine complex as catalyst. Tin(2-ethylhexanoate) was used as reducing agent for ARGET ATRP, and simultaneously acted as a catalyst for ring-opening polymerization of oxirane ring in GMA. The kinetics shows that the double bond in GMA was completely polymerized in 4.0 h, while only a 33% conversion of oxirane ring in GMA was reached at 117.0 h. Such a large difference would guarantee a smooth PISA and a subsequent in situ crosslinking of formed nanoparticles. The transmission electron microscopy and dynamic light scattering show spherical nanoparticles formed. With a feed molar ratio [BnMA]0/[GMA]0 = 150/50, 100/100, and 50/150, the nanoparticles formed in ethanol can dissociate or swell in toluene. When pure GMA was used, the solid nanoparticles were observed in toluene or ethanol. The ARGET ATRP provides an efficient strategy to stabilize the nanoparticles formed in the PISA of GMA-containing system. After reading the article, we found that the author used Cupric bromide(cas: 7789-45-9Safety of Cupric bromide)
Some reported applications of Cupric bromide(cas: 7789-45-9) are: catalyst in cross coupling reactions; co-catalyst in Sonogashira coupling; lewis acid in enantioselective addition of alkynes.Safety of Cupric bromide
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”