Copper-catalysed synthesis of trifluoromethyl allenes via fluoro-carboalkynylation of alkenes was written by Wang, Mengning;Wang, Qiuzhu;Ma, Mengtao;Zhao, Binlin. And the article was included in Organic Chemistry Frontiers in 2022.Related Products of 34946-82-2 This article mentions the following:
A copper-catalyzed synthesis of trifluoromethyl allenes utilizing readily available feedstocks under mild and environmentally friendly conditions was developed, which provided an operationally simple and practical platform for the preparation of substituted allenes with a broad substrate scope. Mechanistic explorations showed that a radical-mediated fluorocarboalkynylation and base-promoted step-wise isomerization of β-CF3 alkynes were responsible for the formation of the desired allenes. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Related Products of 34946-82-2).
Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. Transition metal-catalyzed chemical transformation of organic electrophiles and organometallic reagents belong to the most important cross-coupling reaction in organic synthesis. The copper-mediated C-C, C-O, C-N, and C-S bond formation is a part of one oldest reaction, emphasizing the Ullmann cross-coupling reaction.Related Products of 34946-82-2
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”