Cu-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of N-2,2,2-Trifluoroethylisatin Ketimines Enables the Desymmetrization of N-Arylmaleimides: Access to Enantioenriched F3C-Containing Octahydropyrrolo[3,4-c]pyrroles was written by Wang, Zhen-Hua;Liu, Ji-Hong;Zhang, Yan-Ping;Zhao, Jian-Qiang;You, Yong;Zhou, Ming-Qiang;Han, Wen-Yong;Yuan, Wei-Cheng. And the article was included in Organic Letters in 2022.HPLC of Formula: 34946-82-2 This article mentions the following:
With a Cu(OTf)2/chiral ferrocenyl P,N-ligand complex as a catalyst, the enantioselective desymmetrization of N-arylmaleimides was successfully realized by taking advantage of the asym. 1,3-dipolar cycloaddition reaction of N-2,2,2-trifluoroethylisatin ketimines. A series of structurally diverse F3C-containing octahydropyrrolo[3,4-c]pyrroles I [R1 = H, 4-Br, 6-F, etc.; R2 = Me, Et, allyl, Bn], bearing four contiguous carbon stereocenters and one stereogenic chiral C-N axial bond, were obtained with excellent results. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2HPLC of Formula: 34946-82-2).
Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. Transition metal-catalyzed chemical transformation of organic electrophiles and organometallic reagents belong to the most important cross-coupling reaction in organic synthesis. It is clear from the impact copper catalysis has had on organic synthesis that copper should be considered a first line catalyst for many organic reactions.HPLC of Formula: 34946-82-2
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”