Fields, Ashley M.; Welle, Kevin; Ho, Elaine S.; Mesaros, Clementina; Susiarjo, Martha published the article 《Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice》. Keywords: vitamin B6 deficiency gestational diabetes serotonin pancreatic islets signaling.They researched the compound: 4-Hydroxyquinoline-2-carboxylic Acid( cas:492-27-3 ).Category: copper-catalyst. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:492-27-3) here.
In pancreatic islets, catabolism of tryptophan into serotonin and serotonin receptor 2B (HTR2B) activation is crucial for β-cell proliferation and maternal glucose regulation during pregnancy. Factors that reduce serotonin synthesis and perturb HTR2B signaling are associated with decreased β-cell number, impaired insulin secretion, and gestational glucose intolerance in mice. Albeit the tryptophan-serotonin pathway is dependent on vitamin B6 bioavailability, how vitamin B6 deficiency impacts β-cell proliferation during pregnancy has not been investigated. In this study, we created a vitamin B6 deficient mouse model and investigated how gestational deficiency influences maternal glucose tolerance. Our studies show that gestational vitamin B6 deficiency decreases serotonin levels in maternal pancreatic islets and reduces β-cell proliferation in an HTR2B-dependent manner. These changes were associated with glucose intolerance and insulin resistance, however insulin secretion remained intact. Our findings suggest that vitamin B6 deficiency-induced gestational glucose intolerance involves addnl. mechanisms that are complex and insulin independent.
This literature about this compound(492-27-3)Category: copper-catalysthas given us a lot of inspiration, and I hope that the research on this compound(4-Hydroxyquinoline-2-carboxylic Acid) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”