The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride( cas:89396-94-1 ) is researched.Recommanded Product: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride.Saruta, Takao; Omae, Teruo; Kuramochi, Morio; Iimura, Osamu; Yoshinaga, Kaoru; Abe, Keishi; Ishii, Masao; Watanabe, Tsutomu; Takeda, Tadanao published the article 《Imidapril hydrochloride in essential hypertension: A double-blind comparative study using enalapril maleate as a control》 about this compound( cas:89396-94-1 ) in Journal of Hypertension. Keywords: imidapril hydrochloride enalapril maleate antihypertensive. Let’s learn more about this compound (cas:89396-94-1).
The objective was to assess the value of using imidapril hydrochloride (ACE/TA-6366), a long-acting angiotensin converting enzyme (ACE) inhibitor developed in Japan, to treat patients with essential hypertension. A double-blind, comparative, phase III study was carried out using enalapril maleate as a control, with a 4-wk observation period and a 12-wk treatment period. Both drugs were started at a dose of 5 mg once a day, increasing to 10 mg in patients whose antihypertensive response was insufficient after 4 wk. The study included 231 outpatients aged 30-74 yr; of these, 108 in the imidapril group and 115 in the enalapril group were assessed. There were no differences in background factors between groups. An adequate antihypertensive effect was observed in 71.3% (77/108) in the imidapril group and in 66.1% (76/115) in the enalapril group, with no significant difference between groups. The pulse rate was unchanged in both groups. The drug had no adverse effects in 86.1% (93/108) of the imidapril group and 79.1% (91/115) of the enalapril group, with no significant difference between groups. Adverse drug effects were observed in 5.6% (6/108) of the imidapril group and 12.2% (14/115) of the enalapril group. Cough was the most frequent side effect, reported in 0.9% (1/108) of the imidapril group and 7.0% (8/115) of the enalapril group. Other side effects were reported in 4.6% (5/108) of the imidapril group and 5.2% (6/115) of the enalapril group. Abnormal laboratory values were observed in 3.7% (4/108) of the imidapril group and 0.9% (1/115) of the enalapril group. Imidapril showed excellent clin. efficacy and safety compared to enalapril. The low incidence of cough is of particular interest.
As far as I know, this compound(89396-94-1)Recommanded Product: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”