So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Stanisz, Beata; Regulska, Katarzyna; Kolasa, Kinga researched the compound: (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid hydrochloride( cas:89396-94-1 ).COA of Formula: C20H28ClN3O6.They published the article 《UV derivative spectrophotometric and RP-HPLC methods for determination of imidapril hydrochloride in tablets and for its stability assessment in solid state》 about this compound( cas:89396-94-1 ) in Acta Poloniae Pharmaceutica. Keywords: imidapril stability spectroscopy HPLC quality control. We’ll tell you more about this compound (cas:89396-94-1).
Two methods for determination of imidapril hydrochloride (IMD) in the form of tablets were developed and the stability-indicative determination of IMD in solid state formulations by means of the proposed methods was investigated. IMD is not a pharmacopeial raw material, therefore there is no official method for its determination and purity assessment. The following anal. techniques were adopted for IMD determination: reverse-phase high performance liquid chromatog. (RP-HPLC) and first derivative (1D) UV spectrophotometry. RP-HPLC anal. was performed with the use of LiChrosfer RP-18 column as a stationary phase and acetonitrile-methanol-phosphate buffer pH 2.0 (60:10:30 volume/volume/v) as a mobile phase. The proposed method showed good linearity (in a range 40.0 – 400.0 μg/mL), accuracy, precision and selectivity for: IMD, its degradation product, and for oxymetazoline as an internal standard (IS). Addnl., different spectrophotometric methods were tested, and the first derivative spectrophotometry was accepted for further research. This method showed good linearity (in a range 4.0 – 40.0 μg/mL), precision and accuracy. The proposed methods were successfully applied to the pharmaceutical dosage form containing the investigated compound without any interference from the excipients. Finally, the results of the suggested methods were statistically compared using t-Student and F-Snedecor tests in the assessment for their equivalence.
From this literature《UV derivative spectrophotometric and RP-HPLC methods for determination of imidapril hydrochloride in tablets and for its stability assessment in solid state》,we know some information about this compound(89396-94-1)COA of Formula: C20H28ClN3O6, but this is not all information, there are many literatures related to this compound(89396-94-1).
Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”