Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 89396-94-1, is researched, Molecular C20H28ClN3O6, about An angiotensin converting enzyme inhibitor suppresses contrast media induced renal dysfunction in a murine model of subtotal nephrectomy, the main research direction is ACE inhibitor contrast media nephrectomy renal dysfunction.SDS of cas: 89396-94-1.
Backgrounds: Contrast media (CM)-induced nephropathy (CIN) affects morbidity and mortality in humans. Although CIN is mediated by several factors including the renin-angiotensin system (RAS), little is known about the pathophysiol. To clarify the mechanism, we developed a novel murine CIN model. Methods: We made 5/6 subtotal nephrectomy (NTX) and administered CM (iopamidol) i.v. into the mice 4 wk after NTX. Mice received an angiotensin converting enzyme inhibitor (ACEI, n = 6), an angiotensin II receptor blocker (ARB, n = 4), or ACEI plus a bradykinin B2 receptor antagonist (Hoe-140, n = 5) daily. Results: Serum creatinine levels were significantly elevated in the NTX group compared to the non-NTX group on day 28. A day after CM injection, creatinine levels were addnl. elevated in the non-treated group. While ACEI treatment significantly suppressed the creatinine levels, ARB treatment did not decrease the levels. Hoe-140 negated ACEI’s ability to suppress renal dysfunction. Conclusion: ACEI treatment may be useful for the prevention of CM-induced nephropathy.
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Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”