Computed Properties of C10H7NO3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-Hydroxyquinoline-2-carboxylic Acid, is researched, Molecular C10H7NO3, CAS is 492-27-3, about Kynurenic acid in neurodegenerative disorders-unique neuroprotection or double-edged sword?. Author is Ostapiuk, Aleksandra; Urbanska, Ewa M..
A review. The family of kynurenine pathway (KP) metabolites includes compounds produced along two arms of the path and acting in clearly opposite ways. The equilibrium between neurotoxic kynurenines, such as 3-hydroxykynurenine (3-HK) or quinolinic acid (QUIN), and neuroprotective kynurenic acid (KYNA) profoundly impacts the function and survival of neurons. This comprehensive review summarizes accumulated evidence on the role of KYNA in Alzheimer′s, Parkinson′s and Huntington′s diseases, and discusses future directions of potential pharmacol. manipulations aimed to modulate brain KYNA. The synthesis of specific KP metabolites is tightly regulated and may considerably vary under physiol. and pathol. conditions. Exptl. data consistently imply that shift of the KP to neurotoxic branch producing 3-HK and QUIN formation, with a relative or absolute deficiency of KYNA, is an important factor contributing to neurodegeneration. Targeting specific brain regions to maintain adequate KYNA levels seems vital; however, it requires the development of precise pharmacol. tools, allowing to avoid the potential cognitive adverse effects. Boosting KYNA levels, through interference with the KP enzymes or through application of prodrugs/analogs with high bioavailability and potency, is a promising clin. approach. The use of KYNA, alone or in combination with other compounds precisely influencing specific populations of neurons, is awaiting to become a significant therapy for neurodegenerative disorders.
This literature about this compound(492-27-3)Computed Properties of C10H7NO3has given us a lot of inspiration, and I hope that the research on this compound(4-Hydroxyquinoline-2-carboxylic Acid) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”