Asymmetric Alkynylation of Tertiary Carbon-Centered Radical via Copper-Catalyzed Radical Relay was written by Wu, Dunqi;Wu, Lianqian;Chen, Pinhong;Liu, Guosheng. And the article was included in Chinese Journal of Chemistry in 2022.Application of 34946-82-2 This article mentions the following:
Alkynes are frequently found in a high proportion of natural products and bioactive moleculars, as well as a common synthon in organic synthesis, which can be easily transformed to an alkenyl, alkyl, heteroaryl, or carboxylic acid group. The enantioselective construction of alkyne substituted all carbon quaternary stereocenters is rarely reported and still a big challenge. As part of the continuous effort on developing asym. radical transformations, it was found that introducing an amidyl group (CONHAr) adjacent to the tertiary carbon radical could enable the asym. radical coupling with alkyne reagents. The amidyl group may stabilize the tertiary carbon radical or coordination with the chiral copper catalyst. Herein, a copper-catalyzed asym. trifluoromethyl-alkynylation of α-aryl substituted acrylamides, which provides a straightforward and efficient access to chiral quaternary all-carbon centers bearing alkynyl groups in good yields and enantioselectivities is reported. This reaction was also applied for the synthesis of chiral functionalized dipeptide. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Application of 34946-82-2).
Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. Transition metal-catalyzed chemical transformation of organic electrophiles and organometallic reagents belong to the most important cross-coupling reaction in organic synthesis. Copper nanoparticles can also catalyze the coupling reaction of phenols, thiols, xanthogenates, nitrogen-containing nucleophiles, selenium ruthenium nucleophiles and the like.Application of 34946-82-2
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”