Regioselective Alkylpolyfluoroarylation of Styrenes by Copper-Catalyzed C(sp3)-H and C(sp2)-H Double Activation was written by Zheng, Chenggong;Yan, Fangpei;Liu, Yaomei;Chen, Rui;Zheng, Kaiting;Xiao, Hua;Li, Xiao-Xuan;Feng, Yi-Si;Fan, Shilu. And the article was included in Organic Letters in 2022.Application of 34946-82-2 This article mentions the following:
A novel dehydrogenative dicarbofunctionalization of vinyl arenes ArCH=CHR (Ar = Ph, thiophen-2-yl, 2H-1,3-benzodioxol-5-yl, etc.; R = H, Me) with polyfluoroarenes I (R1 = F, OMe, Ph, etc.) and inactivated alkanes such as cyclohexane, cyclopentane, cycloheptane, etc. enabled by copper catalysis has been accomplished under mild conditions. This transformation provides a regioselective route to highly functionalized polyfluoroaryl compds II (R2 = cyclopentyl, cyclohexyl, cycloheptyl, etc.) that occur as structural scaffolds in a variety of pharmaceuticals and materials. Preliminary mechanistic studies indicate that the carbon-based radical and copper intermediate are involved in the reaction, and the reaction pathway is dominated by the bond dissociation energy (BDE) of C(sp3)-H bonds. In the experiment, the researchers used many compounds, for example, Copper(II) trifluoromethanesulfonate (cas: 34946-82-2Application of 34946-82-2).
Copper(II) trifluoromethanesulfonate (cas: 34946-82-2) belongs to copper catalysts. The transition metal-catalyzed chemical transformation of organic electrophiles and organometallic reagents has turned up as an exceedingly robust synthetic tool. It is clear from the impact copper catalysis has had on organic synthesis that copper should be considered a first line catalyst for many organic reactions.Application of 34946-82-2
Referemce:
Copper catalysis in organic synthesis – NCBI,
Special Issue “Fundamentals and Applications of Copper-Based Catalysts”